Project Details

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Point-of-care biosensing of human tears for dry eye disease

Company: PSU & Innsight Tech, Inc.

Major(s):
Primary: BME
Secondary: EE
Optional: CMPEN, CMPSC

Non-Disclosure Agreement: NO

Intellectual Property: NO

Innsight Tech is developing a reliable electrochemical platform technology to quantify tear fluid biomarkers and guide medical decisions. The value proposition is to strategically manage eye and systemic health conditions via non-invasive tear-fluid biomarkers. The company was co-founded in 2014 by Prof. Dipanjan Pan and Dr. Leanne Labriola (Ophthalmologist). The company's first product is a multiplexed tear fluid biomaker test for dry eye disease. Company website: https://www.innsightech.com/ The company's product on dry eye disease is OcuCheck, which simultaneously measures MMP-9 and tear film osmolarity on one test strip. With a sophisticated electrochemical sensor, the OcuCheck offers highly sensitive measurements and low limits of detection, surpassing competitors. The OcuCheck complements clinical exams for dry eye patients, enabling objective tracking of treatment response and disease progression. The platform work like an at home glucose monitor except no finger pricking is necessary. Familiarity with electrical/electrochemical sensing and Nyquist plot would be helpful. The Learning Factory design team will work with Prof. Pan's lab at Penn State and Innsight Team to 1) take the electrochemical traces from the device and normalize it to the base sensor impedance; 2) apply signal processing to get the best realiable electrochemical features and automate the process; 3) develop an user friendly app to go with the measurements.